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PRO-AAS EC is a brand name for Aspirin (also known as Acetylsalicylic Acid), supplied as a tablet (delayed-release). The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: AND CLINICAL USE Acetylsalicylic acid (ASA) is indicated for fever and the relief of mild to moderate pain of a variety of conditions such as, ache and pains, cold and flu, headache, arthritis or rheumatism, migraine, menstrual cramps, following dental work or intervention, toothache, muscle sprains and strains.…
Verbatim from this product's HC label. Tap a section to expand.
Analgesic, antipyretic, and anti-inflammatory PRO-AAS – 80 (Croquable) :
Children: Under 2 years: as directed by a physician;2 to 3 years: 2 tablets: 4 to 5 years: 3 tablets; 6 to 8 years: 4 tablets; 9 to 10 years: 5 tablets; 11 years: 6 tablets. Dosages may be repeated every 4 hours, not more than 5 times daily.
PRO-AAS EC - 80 : dosage is as directed by a physician.
Previously mentioned guidelines can be used):
Children’s dosage: Under 6 years: as directed by a physician 6, 7 and 8 years: 4 tablets 9 and 10 years: 5 tablets 11 years and older: 6 tablets Dosage may be repeated every 4 hours, not more than 5 times daily. PRO-AAS – 80 (Croquable) & PRO-AAS EC - 80 Prescribing Information Page 6 of 11 PHARMACEUTICAL INFORMATION Drug Substance Proper Name: Acetylsalicylic acid Chemical Names: 2-(Acetyloxy) benzoic acid; Salicylic acid acetate.
16 g/mol Physicochemical Properties Description: White granules, commonly tabular or needle-like, or white crystalline powder. Odorless or having a faint odor.
Solubility:
Slightly soluble in water; freely soluble in alcohol; soluble in chloroform and ether; sparingly soluble in absolute ether. 49 Melting Point: 135°C (rapid heating) PRO-AAS – 80 (Croquable) & PRO-AAS EC - 80 Prescribing Information Page 7 of 11 COMPOSITION PRO-AAS – 80 (Croquable) Each chewable tablet contains 80 mg acetylsalicylic acid as active ingredient.
Non-medicinal ingredients:
DC Yellow #10, FDC Red #40, Mannitol, Natural Orange Flavor, Pregelatinized Starch, Sodium Saccharin, Stearic Acid. PRO-AAS EC - 80 Each tablet contains 80 mg acetylsalicylic acid as active ingredient.
Non-medicinal ingredients:
Colloidal Silicon Dioxide, Glyceryl Stearate, Lactose Anhydrous, Methacrylic Acid Copolymer, Methylated Silica, Methylcellulose, Polydimethylsiloxane, Polysorbate, Pregelatinized Starch, Sodium Bicarbonate, Sodium Lauryl Sulfate, Stearic Acid, Sorbic acid, Sulfuric Acid, Talc, Titanium Dioxide, Triethyl Citrate.
AVAILABILITY OF DOSAGE FORM PRO-AAS – 80 (Croquable) Each salmon, round, biconvex, tablet scored on one side, and debossed “ASA 80” on the other side; contains 80 mg acetylsalicylic acid. In packages of, 100 and 500 tablets. PRO-AAS EC - 80 Each round, white enteric-coated tablet contains 80 mg acetylsalicylic acid.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Aspirin in Canada.
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In packages of 500 and 1000 tablets. STABILITY AND STORAGE RECOMMENDATIONS Store at room temperature (15°-30°C). 8 PHARMACOLOGY Absorption, distribution, metabolism and excretion When ASA is taken orally, it is rapidly absorbed from the stomach and proximal small intestine.
The gastric mucosa is permeable to the non-ionized form of acetylsalicylic acid, which passes through the stomach wall by a passive diffusion process. 10. Absorption in the small intestine occurs at a significantly faster rate than in the stomach.
2 mg within an hour. Within the same period of time, half or more of the ingested dose is hydrolyzed to salicylic acid by esterases in the gastrointestinal mucosa and the liver, the total plasma salicylate concentration reaching a peak between one or two hours after ingestion, averaging between 3 and 7 mg.
, all affect absorption. Distribution of salicylate throughout most body fluids and tissues proceeds at a rapid rate after absorption. Aside from the plasma itself, fluids which have been found to contain substantial amounts of salicylate after oral ingestion include spinal, peritoneal and synovial fluids, saliva and milk.
Tissues containing high concentrations of the drug are the kidney, liver, heart and lungs. Concentrations in the brain are usually low, and are minimal in feces, bile and sweat. The drug readily crosses the placental barrier. At clinical concentrations, from 50% to 90% of the salicylate is bound to plasma proteins especially albumin, while acetylsalicylic acid itself is bound to only a very limited extent.
However, ASA has the capacity of acetylating various proteins, hormones, DNA, platelets and hemoglobin, which at least partly explains its wide- ranging pharmacological actions. The liver appears to be the principal site for salicylate metabolism, although other tissues may also be involved.
The three chief metabolic products of ASA or salicylic acid are salicyluric acid, the ether or phenolic glucuronide and the ester or acyl glucuronide. A small fraction is also converted to gentisic acid and other hydroxybenzoic acids.
The half-life of ASA in the circulation is from 13 to 19 minutes so that the blood level drops quickly after absorption is complete. 5 hours, which means that 50% of the ingested dose leaves the circulation within that time. Excretion of salicylates occurs principally via the kidney, through a combination of glomerular filtration and tubular excretion, in the form of free salicylic acid, salicyluric acid, as well as phenolic and acyl glucuronides.
Salicylate can be detected in the urine shortly after its ingestion but the full dose requires up to 48 hours for complete elimination. The rate of excretion of free salicylate is extremely variable, reported recovery rates in human urine ranging from 10% to 85%, depending largely on urinary pH.
In general, it can be stated that acid urine facilitates reabsorption of salicylate by renal tubules, while alkaline urine promotes excretion of the drug. Analgesia The analgesic effect of ASA has been […]