PMS-TOPIRAMATE

1 Pregnancy 2026-02 Table of Contents Certain sections or subsections that are not applicable at the time of the preparation of the most recent authorized product monograph are not listed. 4 1. 1. 2. 4 2. 4 4. 1. 2. 1. Discontinuing Treatment.........................................................................................

4. 5. 8 5. 8 6. 9 7. 9 Carcinogenesis and Genotoxicity ....................................................................................... 10 Driving and Operating Machinery ......................................................................................

10 Endocrine and Metabolism................................................................................................ 10 Hepatic/Biliary/Pancreatic.................................................................................................

15 Monitoring and Laboratory Tests....................................................................................... 15 Neurologic ........................................................................................................................

16 Ophthalmologic ................................................................................................................ 17 Psychiatric ........................................................................................................................

1 Special Populations ................................................................................................ 4. 27 8. Adverse Reactions ............................................................................................................

1. Adverse Reaction Overview.................................................................................... 2 Clinical Trial Adverse Reactions .............................................................................. 3 Less Common Clinical Trial Adverse Reactions ........................................................

5 Post-Market Adverse Reactions.............................................................................. 2 Drug Interactions Overview.................................................................................... 4 Drug-Drug Interactions ..........................................................................................

5. Drug-Food Interactions .......................................................................................... 6. Drug-Herb Interactions .......................................................................................... 7.

Drug-Laboratory Test Interactions .......................................................................... 56 10. Clinical Pharmacology.......................................................................................................