PDP-PYRAZINAMIDE

, 40-50 mg per kg of body weight per day for prolonged periods of time. Rare incidence: maculopapular rash, fever, acne, porphyria, dysuria, and photosensitivity with reddish- brown discoloration of exposed skin. DOSAGE AND ADMINISTRATION Since bacterial resistance may develop rapidly when pyrazinamide is administered alone in the treatment of tuberculosis, it should only be administered concurrently with other antituberculosis agents.

Usual adult and adolescent dose Tuberculosis - In combination with other antitubercular drugs: oral, 15 to 30 mg per kg of body weight once a day; or 50 to 70 mg per kg of body weight two or three times a week, depending on the treatment regimen.

Note: the usual dose of pyrazinamide for persons infected with human immunodeficiency virus (HIV) is 20 to 30 mg per kg of body weight per day for the first two months of therapy. Usual adult prescribing limits Up to a maximum of 2 grams when taken daily, 3 grams per dose for the three times a week regimen, 4 grams per dose for the two times a week regimen.

Pediatric dose if indicated 30 mg per kg of body weight daily or less. Note: the usual maximum dose in children is 2 grams when taken daily, 3 grams per dose for the three times a week regimen, 4 grams per dose for the two times a week regimen.

11 g/mol Description: Pyrazinamide, a derivative of niacinamide, is a synthetic antituberculosis agent. The drug occurs as a white to practically white, odorless or practically odorless, crystalline powder and is sparingly soluble in water and slightly soluble in alcohol.

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Composition: pdp-PYRAZINAMIDE (pyrazinamide) tablets contain:

Pyrazinamide, USP Non-medicinal Ingredients: Pregelatinized Starch, Corn Starch, Microcrystalline Cellulose, Stearic Acid, Colloidal Silicon Dioxide STABILITY AND STORAGE RECOMMENDATIONS pdp-PYRAZINAMIDE Tablets should be stored between 15° C and 30°C.

Store in a tightly closed container. AVAILABILITY Each white, round, biconvex tablet debossed “pms” on one side and scored on the other side, contains: Pyrazinamide, USP 500 mg. Available in bottles of 100 tablets. pdp-PYRAZINAMIDE – Prescribing Information Page 8 of 11 READ THIS FOR SAFE AND EFFECTIVE USE OF YOUR MEDICINE PATIENT MEDICATION INFORMATION pdp-PYRAZINAMIDE Pyrazinamide Tablets, USP Read this carefully before you start taking pdp-PYRAZINAMIDE and each time you get a refill.

This leaflet is a summary and will not tell you everything about this drug. Talk to your healthcare professional about your medical condition and treatment and ask if there is any new information about pdp-PYRAZINAMIDE. What is pdp-PYRAZINAMIDE used for?

 pdp-PYRAZINAMIDE is used along with other antituberculosis agents to treat all forms of tuberculosis (an infection of the lungs).  Antibacterial drugs like pdp-PYRAZINAMIDE treats only bacterial infections. They do not treat viral infections such as the common cold.