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IPG-LETROZOLE is a brand name for Letrozole, supplied as a tablet. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: AND CLINICAL USE.................................................................................................................3 CONTRAINDICATIONS ......................................................................................................................................4 WARNINGS AND PRECAUTIONS…
Verbatim from this product's HC label. Tap a section to expand.
Dosing Considerations Insufficient data available to recommend dose adjustment in patients with severe hepatic impairment (see Hepatic impairment section). 5 mg tablet once daily. In the adjuvant setting, the intended duration of treatment is 5 years.
In the extended adjuvant setting, treatment with IPG-LETROZOLE (letrozole) is intended for 5 years and should be initiated within 3 months of completion of approximately 5 years of prior standard adjuvant tamoxifen therapy. In the first- and second-line advanced breast cancer settings, IPG-LETROZOLE treatment should continue until further tumour progression is evident.
Special populations Hepatic impairment:
No dose adjustment of letrozole is required for patients with mild to moderate hepatic impairment (Child-Pugh score A or B). Insufficient data are available to recommend a dose adjustment in breast cancer patients with severe hepatic impairment (Child-Pugh C).
Therefore, patients with severe hepatic impairment should be kept under close supervision for adverse events (see WARNINGS AND PRECAUTIONS section) Renal impairment: No dosage adjustment is required for patients with renal impairment with a creatinine clearance (CLcr) ≥10 mL/min.
Insufficient data are available in cases of renal impairment with CLcr <10 mL/min. (see WARNINGS AND PRECAUTIONS section).
Pediatrics (<18 years of age):
Letrozole is contraindicated in children and adolescents. The safety and efficacy of letrozole in children and adolescents (under 18 years of age) have not been established.
Geriatrics (>65 years of age):
No dose adjustment is required for elderly patients. Missed Dose The missed dose should be taken as soon as the patient remembers. However, if it is almost time for the next dose, the missed dose should be skipped, and the patient should go back to her regular dosage schedule.
5 mg or above, over proportionality in systemic exposure was observed (see ACTION AND CLINICAL PHARMACOLOGY). Administration Letrozole should be taken orally and can be taken with or without food (See Drug-Food Interactions section) Page 28 of
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Letrozole in Canada.
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Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.