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CHOLEDYL EXPECTORANT is a brand name for Oxtriphylline, supplied as a solution. The medicine, its uses, side effects and dosage are the same regardless of brand.
Verbatim from this product's HC label. Tap a section to expand.
The following adverse reactions have been observed with choline theophyllinate, but there has not been enough systematic collection of data to support an estimate of their frequency. The most consistent adverse reactions are usually due to overdosage.
Adverse reactions reported with theophylline preparations include:
Gastrointestinal Tract Nausea, vomiting, upper abdominal discomfort, epigastric pain, anorexia, reactivation of peptic ulcers, abdominal cramps, diarrhea, intestinal bleeding, hematemesis. Central Nervous System Headache, nervousness, insomnia, dizziness, lightheadedness, excitement, irritability, restlessness, reflex hyperexcitability, muscle twitching, clonic and tonic generalized convulsions.
Cardiovascular System Palpitation, sinus tachycardia, increased pulse rate, peripheral vascular constriction and/or collapse, extrasystoles, flushing, hypotension, circulatory failure, ventricular arrhythmias. Urinary Tract Albuminuria, diuresis.
Renal Potentiation of diuresis. Skin Rarely urticaria, generalized pruritus and angioneurotic edema, contact dermatitis, rash, alopecia. Blood Very rarely bone marrow suppression, leukopenia, thrombocytopenia and hemorrhagic diathesis.
have also been reported but their association with theophylline therapy is questionable. Others Tachypnea, hyperglycemia, and inappropriate ADH syndrome. 12 SYMPTOMS AND TREATMENT OF OVERDOSAGE Symptoms: The most consistent reactions observed with toxic overdoses of of CHOLEDYL EXPECTORANT (oxtriphylline-guaifenesin) and its derivatives are: Gastrointestinal: Anorexia, nausea, vomiting, epigastric pain, hematemesis, diarrhea CNS: In addition to those cited above, the patient may exhibit hyperreflexia, fasciculations and clonic and tonic convulsions.
These are especially prone to occur in cases of overdosage in infants and small children. Insomnia, restlessness, mild excitement or irritability, and rapid pulse are the early symptoms of overdosage, which may progress to mild delirium.
Sensory disturbances such as tinnitus or flashes of light are common. Fever, diuresis; dehydration and extreme thirst are also seen. Severe poisoning results in bloody, syrup-like "coffee ground" vomitus, tremors, tonic extensor spasm interrupted by clonic convulsions, extrasystoles, quickened respiration, stupor and finally coma.
Cardiovascular:
In addition to those outlined above, marked hypotension and circulatory failure may be manifest. Cardiovascular disorders and respiratory collapse, leading to shock, cyanosis and death follow gross overdosages.
Respiratory:
Tachypnea and respiratory arrest may occur.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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Renal:
Albuminuria and microhematuria may occur. Increased excretion of renal tubular cells has been observed. General systemic effects: syncope, collapse, fever and dehydration.
Management:
It is suggested that the management principles (consistent with the clinical status of the patient when first seen) outlined below be instituted. : Guaifenesin is a phenol (carbolic acid) derivative.
Treatment:
When potential oral overdose is established and seizure has not occurred: a) If patient is alert and seen within the early hours after ingestion, induction of emesis may be of value. Gastric lavage may be of greatest value when performed within 1 hour of ingestion.
b) Administer a cathartic. Sorbitol solution is reported to be of value. c) Administer repeated doses of activated charcoal and monitor theophylline serum levels. d) Prophylactic administration of phenobarbital has been shown to increase the seizure threshold in laboratory animals and administration of this drug can be considered.
13 If patient presents with a seizure: a) Establish an airway. b) Administer oxygen. v. diazepam, according to established procedure. If seizures cannot be controlled, the use of general anesthesia should be considered. d) Monitor vital signs, maintain blood pressure and provide adequate hydration.
If post seizure coma is present: a) Maintain airway and oxygenation. b) If coma is a result of oral medication, follow above recommendations to prevent absorption of the drug, but intubation and lavage will have to be performed instead of inducing emesis, and the cathartic and charcoal will need to be introduced via a large bore gastric lavage tube.
c) Continue to provide full supportive care and adequate hydration until the drug is metabolized. d) In general, drug metabolism is sufficiently rapid so as not to warrant dialysis. If repeated oral activated charcoal is ineffective (as noted by stable or rising serum levels) charcoal hemoperfusion may be indicated.
Treatment should be supportive and symptomatic; symptoms can often be controlled by CNS depressants such as short-acting barbiturates. v. diazepam. Also parenteral fluids, electrolyte solutions, oxygen and/or therapy for shock may be indicated.
DOSAGE AND ADMINISTRATION Usual maintenance doses of CHOLEDYL EXPECTORANT (oxtriphylline-guaifenesin): Patients over 14 years: 10 mL 4 times daily; 10 to 14 years: 5 mL 4 times daily. The following mg equivalents facilitate changing from one xanthine preparation to another: theophylline anhydrous 100 mg=aminophylline 118 mg=oxtriphylline 156 mg=theophylline sodium glycinate 200 mg.
4 mg anhydrous theophylline and guaifenesin 50 mg. Nonmedicinal ingredients: alcohol, anethole, citric acid, FD&C Red No. 2, 14 FD&C Yellow No. 6, flavouring agents, glycerin, sodium citrate, sodium cyclamate and sugar. Alcohol: 20%. 7 kcal)/5 mL.
4 mg)/5 mL. Gluten-, lactose-, paraben-, sulfite- and tartrazine-free. Stability and Storage Recommendations Store CHOLEDYL EXPECTORANT (oxtriphylline-guaifenesin) at controlled room temperature 15 to 25°C. AVAILABILITY OF DOSAGE FORMS CHOLEDYL EXPECTORANT […]