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CALCIMAR is a brand name for Calcitonin, supplied as a solution. The medicine, its uses, side effects and dosage are the same regardless of brand.
Verbatim from this product's HC label. Tap a section to expand.
Patients who are hypersensitive to CALCIMAR or to any ingredient in the formulation or component of the container. For a complete listing, see DOSAGE FORMS and PHARMACEUTICAL INFORMATION, Composition sections of the Product Monograph.
4% (intranasal route)) in patients treated with calcitonin therapy compared to patients treated with placebo. Patients in these trials were treated with long-term oral and intra-nasal formulations however it is likely that an increased risk also applies when calcitonin is administered subcutaneously, intramuscularly or intravenously especially for long-term use, as systemic exposure to calcitonin in such patients is expected to be higher than for other formulations.
Pregnancy:
Reproduction studies in two species (rats and rabbits) have revealed decreases in fetal birth weight, and data in humans are not available to exclude a possible adverse effect on the fetus. Use of this drug in women who are or may become pregnant requires a determination that the potential benefit to the patient outweighs the possibility of risk to the fetus.
Nursing Mothers:
CALCIMAR has been shown to inhibit lactation in animals and should not be administered to nursing mothers.
Children (< 18 years of age):
The safe use of CALCIMAR in children has not been established.
PRECAUTIONS Potential allergenicity of CALCIMAR:
Skin testing should be considered prior to treatment of patients with suspected sensitivity to calcitonin. U. P. ). ) on the inner aspect of the forearm. Observe the injection site 15 minutes after injection. The appearance of more than mild erythema or wheal constitutes a positive response.
4 Because calcitonin is protein in nature, the possibility of a systemic allergic reaction cannot be overlooked. Administration of calcitonin-salmon has been reported in a few cases to cause serious allergic-type reactions (for example, bronchospasms, swelling of the tongue or throat and anaphylactic shock), and in one case, death due to anaphylaxis.
The usual provisions should be made for the emergency treatment of such a reaction should it occur. Allergic reactions should be differentiated from generalized flushing and hypotension. e. muscle cramps, twitching). Provisions for parenteral calcium administration should be available during the first several administrations of calcitonin.
In patient’s with active Paget’s disease, a decrease in serum calcium was observed after the injection of up to 100 units of subcutaneous calcitonin, which can be asymptomatic, was evident by the end of the first hour and maximal from 4 to 6 hours.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Calcitonin in Canada.
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Antibody development:
Calcitonin administration can and does lead to antibody development. This is minimal when the hormone is injected in the absence of an adjuvant or when it is not complexed with a larger protein. Gelatin and acetate buffer solutions have been shown to have little or no adjuvant-like action in comparison to Freund's adjuvant.
The antibodies which develop when calcitonin is administered repeatedly with Freund's adjuvant are measurable in the circulation by radio-immunoassay techniques. In no instance has any systemic allergic or anaphylactic effect been reported in animal studies with calcitonin, in spite of the known development of circulating antibodies.
Laboratory Tests:
Periodic examinations of serum calcium and urine sediment of patients on chronic therapy are recommended. Coarse granular casts and casts containing renal tubular epithelial cells were reported in young adult volunteers at bed rest who were given salmon calcitonin to study its effect on immobilization osteoporosis.
There was no other evidence of renal abnormality and the urine sediment became normal after calcitonin was stopped.
Instructions for the patient:
Careful instruction in sterile injection technique should be given to the patient and to other persons who may administer CALCIMAR. 5 INTERACTIONS Concomitant use of CALCIMAR and lithium may lead to a reduction in plasma lithium concentrations.
The dose of lithium may need to be adjusted; blood monitoring of lithium is recommended.
ADVERSE REACTIONS Central and peripheral nervous system disorders:
Paresthesia (tingling of the hands), dizziness, seizures, visual and hearing impairment, headache, tremor, tinnitus.
Endocrine disorders:
Secondary hyperparathyroidism did not develop in patients with Paget's disease as a result of the transient hypocalcemia following calcitonin administration.
Eye disorders:
Pain in the eyes.
Gastrointestinal disorders:
Nausea with or without vomiting has been noted in about 10% of patients treated with CALCIMAR. It is most evident when treatment is first initiated and tends to decrease or disappear with continued administration. Abdominal pain, diarrhea.
General and administration site disorders:
Local inflammatory reactions at the site of injection have been reported in about 10% of patients. Feverish sensation.
Immune system disorders:
Evidence of systemic allergic reactions was minimal. Administration of calcitonin-salmon has been reported in a few cases to cause serious allergic-type reactions (for example, bronchospasms, swelling of the tongue or throat and anaphylactic shock), and in one case, death due to anaphylaxis (see PRECAUTIONS, Potential allergenicity of CALCIMAR).
Skin rashes and pruritus of the ear […]