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BIVALIRUDIN FOR is a brand name for Bivalirudin, supplied as a powder for solution. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: AND CLINICAL USE ..............................................................................3 CONTRAINDICATIONS ...................................................................................................3 WARNINGS AND PRECAUTIONS…
Verbatim from this product's HC label. Tap a section to expand.
DOSING CONSIDERATIONS Bivalirudin for Injection should be administered with ASA. Clopidogrel can also be administered. Patients can be started with Bivalirudin for Injection 30 minutes after discontinuation of UFH given intravenously, or 8 hours after discontinuation of LMWH given subcutaneously.
25 mg / kg / hr prior to angiography and continued through angiography and as long as needed. The dose should be administered before assignment to a procedure (PCI, CABG, or drug therapy management). 25 mg / kg / hr for up to 72 hours.
No dosage adjustment is needed for these patients. 75 mg / kg / hr for the duration of the procedure. 25 mg / kg / hr may be resumed for 4 to 12 hours as clinically necessary. For patients who proceed to CABG surgery off-pump, the intravenous infusion of Bivalirudin for Injection should be continued until the time of surgery.
75 mg / kg / hr infusion for the duration of the surgery. For patients who proceed to CABG surgery on-pump, the intravenous infusion of Bivalirudin for Injection should be continued until 1 hour prior to surgery after which the infusion should be discontinued and the patient treated with unfractionated heparin.
75 mg / kg. 75 mg / kg / hr for the duration of the PCI procedure (see Table 10). 3 mg / kg should be given if needed. GPI administration should be considered in the event that any of the conditions listed in CLINICAL TRIALS, REPLACE-2 is present.
Continuation of the infusion following PCI for up to 4 hours post-procedure is optional, at the discretion of the treating physician. 25 mg / kg / hr may be continued for 4 – 12 hours as clinically necessary. Bivalirudin for Injection-Annotated Page 16 of 42 Bivalirudin for Injection is intended for use with aspirin (300 – 325 mg daily) and has only been studied in patients receiving concomitant aspirin.
In STEMI patients undergoing primary PCI, standard pre-PCI adjunctive therapy should include clopidogrel and may include the early administration of UFH (see CLINICAL TRIALS, HORIZONS). Patients should be carefully monitored following PCI for signs and symptoms consistent with myocardial ischemia.
5 mg / kg / hr intravenous infusion. Bivalirudin for Injection infusion may be terminated approximately 15 minutes prior to the anticipated end of cardiopulmonary bypass (CPB). The ACT may be used to check that the patient is anticoagulated following administration of Bivalirudin for Injection.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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Infusion dose adjustment should not be necessary. For patients in whom hemofiltration is required during bypass, periodic ACT monitoring may be used (see DOSAGE AND ADMINISTRATION, Dosing Pre- and Post- Cardiac Surgery, Medical Management Guidelines for Cardiac Surgery).
5 mg / kg / hr intravenous infusion restarted and continued until 15 minutes prior to the anticipated end of CPB (see DOSAGE AND ADMINISTRATION, Dosing Pre- and Post-Cardiac Surgery, Medical Management Guidelines for Cardiac Surgery for dosing of the CPB pump with Bivalirudin for Injection).
75 mg / kg / hr intravenous infusion for the duration of the procedure. The ACT may be used to check that the patient is anticoagulated following administration of Bivalirudin for Injection. 25 mg / kg / hr increments if a higher level of anticoagulation was desired.
The data suggest that infusion dose adjustments should not be necessary. 5 mg / kg / hr. In addition, see DOSAGE AND ADMINISTRATION, Dosing Pre- and Post-Cardiac Surgery, Medical Management Guidelines for Cardiac Surgery for dosing of the pump.
Dosing Pre- and Post-Cardiac Surgery Bivalirudin for Injection may be used for anticoagulation up to 48 hours prior to surgery or in the postoperative phase up to 14 days after the procedure. 5 times the baseline value.
Medical Management Guidelines for Cardiac Surgery:
CPB Use of Bivalirudin for Injection for anticoagulation during CPB requires little modification to the conventional bypass circuit setup. Before […]