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ARSENIC TRIOXIDE is a brand name for Arsenic Trioxide, supplied as a solution. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: AND CLINICAL USE ..................................................................3 CONTRAINDICATIONS .......................................................................................4 WARNINGS AND PRECAUTIONS ......................................................................4 ADVERSE REACTIONS…
Verbatim from this product's HC label. Tap a section to expand.
Serious Warnings and Precautions Treatment with ARSENIC TRIOXIDE SOLUTION FOR INJECTION may lead to a condition called “APL Differentiation Syndrome” which includes difficulty in breathing, weight gain, coughing, chest pain, fever and may cause death.
ARSENIC TRIOXIDE SOLUTION FOR INJECTION has an effect on the electrical activity of the heart known as prolongation of the QT interval. The prolongation of the QT interval can lead to arrhythmias such as torsade pointes, which may be experienced as dizziness, palpitations and fainting and can result in death.
Before your first dose of ARSENIC TRIOXIDE SOLUTION FOR INJECTION, your doctor will perform a 12-lead electrocardiogram (ECG) and will perform tests to check the amount of potassium, magnesium, calcium and creatinine in your blood.
While taking ARSENIC TRIOXIDE SOLUTION FOR INJECTION, avoid taking drugs that cause a change in the rhythm of your heartbeat or drugs that cause a change in electrolyte levels (potassium, calcium and magnesium). ARSENIC TRIOXIDE SOLUTION FOR INJECTION should be administered under the supervision of a physician who is experienced in the management of patients with acute leukemia.
Treatment with ARSENIC TRIOXIDE SOLUTION FOR INJECTION may cause a condition called Encephalopathy (brain disease) which sometimes may lead to death. BEFORE you use ARSENIC TRIOXIDE SOLUTION FOR INJECTION talk to your doctor or pharmacist if: you have kidney or liver problems; you have any problems with your heart, including irregular heartbeat; you plan to become pregnant.
ARSENIC TRIOXIDE SOLUTION FOR INJECTION may cause harm to the fetus when used by pregnant women. If you are able to become pregnant, you must use effective birth control during treatment with ARSENIC TRIOXIDE SOLUTION FOR INJECTION and 3 months after the ARSENIC TRIOXIDE SOLUTION FOR INJECTION therapy has stopped.
you are pregnant or you become pregnant during the treatment with ARSENIC TRIOXIDE SOLUTION FOR INJECTION, you must ask your doctor for advice; you are breast-feeding. Arsenic will be present in the milk of ARSENIC TRIOXIDE SOLUTION FOR INJECTION patients who are breast-feeding.
Because of the potential for serious side-effects in nursing infants from ARSENIC TRIOXIDE SOLUTION FOR INJECTION, do not breast-feed while on ARSENIC TRIOXIDE SOLUTION FOR INJECTION and 3 months after the ARSENIC TRIOXIDE SOLUTION FOR INJECTION therapy has stopped.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Arsenic Trioxide in Canada.
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Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
Men should also use effective contraception during treatment with ARSENIC TRIOXIDE SOLUTION FOR INJECTION and for 3 months after ARSENIC TRIOXIDE SOLUTION FOR INJECTION therapy has stopped. , ketoconazole, fluconazole, voriconazole) - used to treat infections domperidone - used to treat gastrointestinal disorders dolasetron, ondansetron - used to treat nausea vorinostat , vandetanib, sunitinib, nilotinib, lapatinib -used to treat cancer salmeterol, formoterol - used to treat asthma Any medicines that cause imbalance in the electrolytes in your body: diuretics (water pills) laxatives and enemas amphotericin B high dose corticosteroids Anthracyclines – cancer chemotherapy drugs The above lists of potentially interacting drugs are not comprehensive.
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines even those not prescribed (including any over-the-counter drugs, vitamins, or herbal medicines).
PROPER USE OF THIS MEDICATION Usual dose:
ARSENIC TRIOXIDE SOLUTION FOR INJECTION must be injected under the supervision of a physician experienced in the treatment of acute leukemias. 9%) injection. Your doctor will infuse ARSENIC TRIOXIDE SOLUTION FOR INJECTION through a tube into a blood vessel over 1-2 hours, but the infusion may last longer if side-effects like flushing and dizziness occur.
Your doctor will give you ARSENIC TRIOXIDE SOLUTION FOR INJECTION once every day as a single infusion each day. In your first treatment cycle, you may be treated every day up to 60 days at most, or until your doctor determines that your disease is better.
If your disease responds to ARSENIC TRIOXIDE SOLUTION FOR INJECTION, you will be given a second treatment cycle of 25 doses, given 5 days per week followed by a 2 day break for 5 weeks. Your doctor will decide exactly how long you must continue on therapy with ARSENIC TRIOXIDE SOLUTION FOR INJECTION.
Overdose:
If you experience symptoms suggestive of acute arsenic toxicity such as convulsions, muscle weakness and confusion, ARSENIC TRIOXIDE SOLUTION FOR INJECTION must be stopped immediately and your doctor will treat the arsenic overdose.
In a case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms. […]