Loading…
APO-TRYPTOPHAN is a brand name for Tryptophan, supplied as a tablet. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: APO-TRYPTOPHAN (L-Tryptophan) is indicated: as a valuable adjunct to antidepressant drug treatment in the management of patients suffering from depressive disorders (bipolar affective disorders).
Verbatim from this product's HC label. Tap a section to expand.
2 Recommended Dose and Dosage Adjustment Clinical reports on the use of L-Tryptophan as an adjunct in the management of affective disorders have indicated the dose of 8 to 12 g/day to be the most effective one. Lower doses have been reported to be effective in combination with other antidepressants.
Some patients may not tolerate 12 g/day but might still benefit from doses reduced to 8 g/day. The treatment might be initiated with 12 g per day of APO-TRYPTOPHAN, given in 3 to 4 equally divided doses. • Special Populations and Conditions A small number of bipolar patients are particularly sensitive to L-Tryptophan and will not tolerate higher doses than 1 or 2 g/day.
Patients on concomitant medication should be monitored for possible reduction of the concomitant medication since APO-TRYPTOPHAN may enhance their efficacy. If APO-TRYPTOPHAN is used in the acute treatment of mania in conjunction with lithium it will potentiate some of the side effects associated with lithium such as nausea and vomiting.
Thus, often it will be necessary to decrease the lithium dosage especially when it is given in doses above 900 to 1200 mg/day. In manic-depressive illness chronically treated with lithium, the lithium dose may need to be decreased when APO-TRYPTOPHAN is added because of increased side effects.
4 Drug- Drug interactions). 4 Drug-Drug interactions). 4 Administration Administration with meals or snacks is recommended to reduce the incidence of nausea. 5 Drug-Food Interactions).
1 Adverse Reaction Overview • APO-TRYPTOPHAN, in doses below 5 g/day may cause dry mouth and drowsiness. 4 Administration). • Side effects disappear when medication is continued and, in most cases, only a light dizziness may persist.
• Sexual disinhibition has been reported in some patients with emotional disorders. 4 Drug-Drug Interactions).
, Sensitivity/Resistance). 2 Recommended Dose and Dosage Adjustment Clinical reports on the use of L-Tryptophan as an adjunct in the management of affective disorders have indicated the dose of 8 to 12 g/day to be the most effective one.
Lower doses have been reported to be effective in combination with other antidepressants. Some patients may not tolerate 12 g/day but might still benefit from doses reduced to 8 g/day. The treatment might be initiated with 12 g per day of APO-TRYPTOPHAN, given in 3 to 4 equally divided doses.
• Special Populations and Conditions A small number of bipolar patients are particularly sensitive to L-Tryptophan and will not tolerate higher doses than 1 or 2 g/day. Patients on concomitant medication should be monitored for possible reduction of the concomitant medication since APO-TRYPTOPHAN may enhance their efficacy.
If APO-TRYPTOPHAN is used in the acute treatment of mania in conjunction with lithium it will potentiate some of the side effects associated with lithium such as nausea and vomiting. Thus, often it will be necessary to decrease the lithium dosage especially when it is given in doses above 900 to 1200 mg/day.
In manic-depressive illness chronically treated with lithium, the lithium dose may need to be decreased when APO-TRYPTOPHAN is added because of increased side effects. 4 Drug- Drug interactions). 4 Drug-Drug interactions). 4 Administration Administration with meals or snacks is recommended to reduce the incidence of nausea.
5 Drug-Food Interactions). 5 OVERDOSAGE Symptoms of overdosage would include vomiting and might include serotonin syndrome symptoms. Treatment of overdosage would be symptomatic with close monitoring and support of vital systems as necessary (see 7 WARNINGS AND PRECAUTIONS, General, Serotonin syndrome).
For the most recent information in the management of a suspected drug overdose, contact your regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X (1- 844-764-7669). 6 DOSAGE FORMS, STRENGTHS, COMPOSITION AND PACKAGING Table 1 – Dosage Forms, Strengths, Composition and Packaging Route of Administration Dosage Form / Strength/Composition Non-medicinal Ingredients Oral 500 mg Capsules Croscarmellose sodium, magnesium stearate, methylcellulose and stearic acid.
APO-TRYPTOPHAN (L-Tryptophan) is contraindicated in patients with known sensitivity to L- Tryptophan or any other compound in the formulation (see 7 WARNINGS AND PRECAUTIONS, Sensitivity/Resistance).
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Tryptophan in Canada.
Know a brand we are missing in Canada? Suggest a brand →
Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
Oral 250 mg, 500 mg, 750 mg and 1g Tablets Croscarmellose sodium, magnesium stearate, methylcellulose and stearic acid. The capsule shell contains gelatin and titanium dioxide. The edible black printing ink on the capsule shell contains colouring agent iron oxide black.
• APO-TRYPTOPHAN 250 mg Tablets: each off-white, oval-shaped, biconvex tablet engraved "APO" on one side and “TRY 250” on the other, contains 250 mg of L- Tryptophan. Available in bottles of 100 and 250. • APO-TRYPTOPHAN 500 mg Tablets: each off-white, oval-shaped, biconvex tablet, engraved “APO” on one side and “LTR 500” on the other, contains 500 mg of L- Tryptophan.
Available in bottles of 100 and 250. APO-TRYPTOPHAN (L-Tryptophan Product Monograph) Page 6 of 18 • APO-TRYPTOPHAN 750 mg Tablets: each white to off-white, oval, biconvex tablet, engraved “LTR 750" on one side, “APO” on the other side, contains 750 mg of L- Tryptophan.
Available in bottles of 100. • APO-TRYPTOPHAN 1 g Tablets: each off-white, oval-shaped, biconvex tablet engraved "APO" on one side and “LTR 1000” on the other, contains 1 g of L-Tryptophan. Available in bottles of 100 and 250. • APO-TRYPTOPHAN 500 mg Capsules: each opaque white, hard gelatin capsule, size No.
0 EL, imprinted “APO 500”, contains 500 mg of L-Tryptophan. Available in bottles of 100 and 250. 7 WARNINGS AND PRECAUTIONS General • Monoamine Oxidase Inhibitors (MAOIs) APO-TRYPTOPHAN is not recommended in patients taking monoamine oxidase inhibitors (MAOIs including linezolid, methylene blue) or within 14 days of such therapy.
4 Drug-Drug Interactions). • Serotonin Syndrome There have been rare reports of serotonin syndrome with the concomitant use of L-Tryptophan and serotonergic drugs. Serotonin toxicity also known as serotonin syndrome is a potentially life-threatening condition and has been reported during the use of L-Tryptophan.
g. g. anxiety, agitation, hypomania). 4 Drug-Drug Interactions). If serotonin toxicity is suspected, discontinuation of the serotonergic agents should be considered. Carcinogenesis and […]