Loading…
APO-CEFEPIME is a brand name for Cefepime, supplied as a powder for solution. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: AND CLINICAL USE .................................................................................... 3 CONTRAINDICATIONS .......................................................................................................... 5 WARNINGS AND PRECAUTIONS…
Verbatim from this product's HC label. Tap a section to expand.
APO-CEFEPIME (cefepime for injection) can be administered either intravenously or intramuscularly. The dosage and route of administration should be determined according to the susceptibility of the causative organisms, the severity of the infection, and the condition and renal function of the patient.
Guidelines for dosage of APO-CEFEPIME (cefepime for injection) in adults with normal renal function are provided in Table 1. 5-1 IV or IM q12h 7-10 Mild to moderate infections including pneumonia, bronchitis and skin and skin-structure infections 1 IV or IM q12h 10 Severe infections including pneumonia, septicemia and complicated intra-abdominal infections 2 IV q12h 10 Empiric therapy in febrile neutropenic patients* 2 IV q8h 7** *Cefepime has also been used in combination with an aminoglycoside or a glycopeptide in patient populations which excluded high risk patients (See INDICATIONS AND CLINICAL USE).
** Or until resolution of neutropenia. Pediatric Patients (aged 2 months up to 12 years with normal renal function) Usual recommended dosages Empiric treatment of febrile neutropenia: Patients > 2 months of age with body weight ≤ 40kg: 50 mg/kg IV q8h for 7-10 days.
Pneumonia, urinary tract infections, skin and skin structure infections:
Patients > 2 months of age with body weight ≤ 40 kg: 50 mg/kg IV q12h for 10 days. Experience with the use of cefepime for injection in pediatric patients < 2 months of age is limited. For pediatric patients with body weights > 40kg, adult dosing recommendations apply (see Table 1).
Dosage in pediatric patients should not exceed the maximum Page 12 of 40 recommended dosage in adults (2 g q8h). Experience with intramuscular administration in pediatric patients is limited. Infection The usual duration of therapy is 7-10 days; however, more severe infections may require longer treatment.
Impaired Hepatic Function:
No adjustment is necessary for patients with impaired hepatic function. Impaired renal function There is no need to adjust dosage in the elderly unless renal impairment is present. Cefepime is excreted by the kidneys almost exclusively by glomerular filtration.
Therefore, in patients with impaired renal function (creatinine clearance ≤ 50 mL/min), the dose of cefepime should be adjusted to compensate for the slower rate of renal elimination. The recommended initial dose of cefepime in patients with mild to moderate renal impairment should be the same as in patients with normal renal function.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Cefepime in Canada.
Know a brand we are missing in Canada? Suggest a brand →
Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
An estimate of creatinine clearance should be made to determine the appropriate maintenance dose. 73 m2) > 50 Normal recommended dosing schedules, no adjustments needed 1 g q 12h 2 g q 12h 2 g q 8h 30-50 1 g q 24h 2 g q 24h 2 g q 12 h 11 – 29 500 mg q24h 1 g q24h 2 g q24h < 11 250 mg q24h 500 mg q24h 1 g q24h Hemodialysis* 500 mg q24h 500 mg q24h 500 mg q24h * Pharmacokinetic modeling indicates that reduced dosing for these patients is necessary.
Patients receiving cefepime who are undergoing concomitant hemodialysis should be dosed as follows: 1 gram loading dose on the first day of cefepime therapy and 500 mg per day thereafter. On dialysis days, cefepime should be administered following dialysis.
Whenever possible cefepime should be administered at the same time each day. When only serum creatinine measurement is available, the following formula (proposed by Cockcroft and Gault) may be used to estimate creatinine clearance. 85 X value calculated using formula for males Pediatric Patients with Impaired Renal Function Since urinary excretion is the primary route of elimination of cefepime in pediatric patients (see ACTION AND CLINICAL PHARMACOLOGY), an adjustment of the dosage of APO-CEFEPIME (cefepime for injection) should also be considered in this population.
A dose of 50 mg/kg in patients aged 2 months up to 12 years is comparable to a dose of 2 g in an adult. As recommended in Table 2, the same increase in interval between doses and/or reduction in dose should be used. 6 serum creatinine (mg/dL) Dialysis Patients: In patients undergoing hemodialysis, approximately 68% of the total amount of cefepime present in the body at the start of dialysis will be removed during a 3-hour dialysis period.
The recommended initial dose and maintenance schedule for patients on hemodialysis are presented in Table 2. , 500 mg, 1 g or 2 g (depending on the severity of the infection) at a dosage interval of every 48 hours.
ROUTE OF ADMINISTRATION Intravenous administration:
The intravenous route of administration is preferable for patients with severe or life-threatening infections, particularly if the possibility of shock is present. For direct intravenous injection, the solution reconstituted as […]