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APO-CAPTO TAB is a brand name for Captopril, supplied as a tablet. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: AND CLINICAL USE Hypertension APO-CAPTO (captopril) is indicated for the treatment of essential or renovascular hypertension. It is usually administered in association with other drugs, particularly thiazide diuretics. The blood pressure lowering effects of captopril and thiazides are approximately additive. In using…
Verbatim from this product's HC label. Tap a section to expand.
APO-CAPTO (captopril) is contraindicated in patients with a history of hypersensitivity to the drug and in patients with a history of angioedema related to previous treatment with an Angiotensin Converting Enzyme inhibitor. 73m2) is contraindicated (see WARNINGS, Dual Blockade of the Renin-Angiotensin System (RAS), PRECAUTIONS, Renal Impairment, and DRUG INTERACTIONS, Dual Blockade of the Renin-Angiotensin-System (RAS) with ACE inhibitors, ARBs or aliskiren-containing drugs).
WARNINGS Serious Warning When used in pregnancy, angiotensin converting enzyme (ACE) inhibitors can cause injury or even death of the developing fetus. When pregnancy is detected, APO-CAPTO should be discontinued as soon as possible.
Angioedema Angioedema has been reported in patients treated with ACE inhibitors, including captopril. Angioedema associated with laryngeal involvement may be fatal. If laryngeal stridor or angioedema of the face, tongue, or glottis occurs, captopril should be discontinued immediately, the patient treated appropriately in accordance with accepted medical care, and carefully observed until the swelling disappears.
In instances where swelling is confined to the face and lips, the condition generally resolves without treatment, although antihistamines may be useful in relieving symptoms. 5 mL of subcutaneous epinephrine solution 1:1000) should be administered promptly (see ADVERSE REACTIONS).
The incidence of angioedema during ACE inhibitor therapy has been reported to be higher in black than in non-black patients. Patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor (see CONTRAINDICATIONS).
Nitritoid Reactions - Gold:
Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and symptomatic hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ACE inhibitor therapy including APO-CAPTO (see DRUG INTERACTIONS).
6 Proteinuria Total urinary proteins greater than 1 g per day were seen in less than one percent of patients receiving captopril. These have been predominantly in those who had prior renal disease, or in those receiving relatively high doses (in excess of 150 mg/day), or both.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Captopril in Canada.
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5%. 2%. Parameters of renal function, such as BUN and serum creatinine were seldom altered in the patients with proteinuria. In most cases, proteinuria subsided or cleared within 6 months whether or not captopril was continued, but some patients had persistent proteinuria.
Nephrotic syndrome occurred in about one-fifth of the proteinuric patients. Membranous glomerulopathy was found in biopsies taken from proteinuric patients. A causal relationship to captopril has not been established since pre-treatment biopsies were not taken and membranous glomerulopathy has been shown to occur in hypertensive patients not receiving captopril.
Since most cases of proteinuria occurred by the eighth month of therapy, patients with prior renal disease or those receiving captopril at doses greater than 150 mg/day should have urinary protein estimations (dipstick on first morning urine or quantitative 24-hour urine) prior to therapy, at approximately monthly intervals for the first 9 months of treatment, and periodically thereafter.
When proteinuria is persistent, 24-hour quantitative determinations provide greater precision. For patients who develop proteinuria exceeding 1 g/day, or proteinuria that is increasing, the benefits and risks of continuing captopril should be evaluated.
Neutropenia/Agranulocytosis Neutropenia, (<1000/mm3) with myeloid hypoplasia has resulted from use of captopril. About half of the neutropenic patients developed systemic or oral cavity infections or other features of the syndrome of agranulocytosis.
6 mg/dL and no collagen disease), neutropenia has been seen in one patient out of over 8600 exposed. 6 mg/dL) but no collagen vascular disease, the risk of neutropenia in clinical trials was about 1 per 500, a frequency over 15 times that for uncomplicated hypertension.
Daily doses of captopril were relatively high in these patients, particularly in view of their diminished renal function. In patients with renal failure, use of allopurinol concomitantly with captopril has been associated with neutropenia.
7% of patients in clinical trials. While none of the over 750 patients in formal clinical trials of heart failure developed neutropenia, it has occurred during the subsequent clinical experience. 6 mg/dL and more than 75% were in patients also receiving procainamide.
In heart failure, it appears that the same risk factors for neutropenia are present. The neutropenia has been detected within 3 months after captopril was started. Bone marrow examinations in patients with neutropenia consistently showed myeloid hypoplasia, frequently accompanied by erythroid hypoplasia and decreased […]