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ACETAZOLAMIDE is a brand name for Acetazolamide, supplied as a tablet. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: ACETAZOLAMIDE (acetazolamide tablets) is indicated: • To decrease ocular aqueous humor secretion in glaucoma (chronic, simple and secondary types). • For use as an adjunct in the treatment of selected cases of epilepsy. • To alkalinize the urine in selected cases of salicylate overdosage. 1.1 Pediatrics Pediatrics: No…
Verbatim from this product's HC label. Tap a section to expand.
2 Recommended Dose and Dosage Adjustment Chronic simple (open angle) glaucoma: 250 mg. 1 to 4 times daily. A complementary effect has been noted when acetazolamide was used with miotics or mydriatics as the case demanded. Secondary glaucoma and preoperative treatment of some cases of acute congestive (closed angle) glaucoma: 250 mg every 4 hours.
Epilepsy: 8 to 30 mg/kg (375 to 1000 mg) daily in divided doses. To alkalinize the urine: 250 mg every 4 to 6 hours. Health Canada has not authorized an indication for pediatric use.
1 Adverse Reaction Overview Metabolic acidosis and hypokalemia may occur during prolonged acetazolamide therapy. Adverse reactions common to all sulfonamide derivatives including fever, rash (including Stevens Johnsons Syndrome, Erythema Multiforme, Toxic Epidermal Necrolysis and Acute Generalised Exanthematous Pustulosis), crystalluria, renal calculus, bone marrow depression, thrombocytopenic purpura, hemolytic anemia, leukopenia, pancytopenia, and agranulocytosis may occur.
If such reactions occur, discontinue therapy and institute appropriate measures. For acute respiratory distress syndrome and pulmonary edema, if rapidly progressive dyspnoea, hypoxaemia, or chest X-ray abnormalities such as diffuse infiltrative shadow in both lungs are observed, administration of this drug should be discontinued, and appropriate measures should be taken.
The frequency of these adverse reactions are not known. ACETAZOLAMIDE (Acetazolamide Tablets) Page 7 of 15 Unclassified / Non classifié Untoward effects during short term therapy are said to be minimal. Those noted include paresthesias, some loss of appetite, polyuria and occasional instances of drowsiness and confusion.
Other occasional adverse reactions include urticaria, melena, hematuria, glycosuria, hepatic insufficiency, flaccid paralysis and convulsions. Transient myopia has been reported. This condition invariably subsided upon the diminution or discontinuation of the medication.
5 Post-Market Adverse Reactions Eye disorders: choroidal effusion, acute myopia, acute angle-closure glaucoma (very rare).
05/2025 TABLE OF CONTENTS Sections or subsections that are not applicable at the time of authorization are not listed. RECENT MAJOR LABEL CHANGES ..........................................................................................
2 TABLE OF CONTENTS ............................................................................................................ 2 PART I: HEALTH PROFESSIONAL INFORMATION ....................................................................
4 1 INDICATIONS ............................................................................................................. 1 Pediatrics................................................................................................................
2 Geriatrics ................................................................................................................ 4 2 CONTRAINDICATIONS ................................................................................................
4 3 SERIOUS WARNINGS AND PRECAUTIONS BOX ........................................................... 4 4 DOSAGE AND ADMINISTRATION................................................................................ 2 Recommended Dose and Dosage Adjustment ......................................................
5 5 OVERDOSAGE............................................................................................................ 5 6 DOSAGE FORMS, STRENGTHS, COMPOSITION AND PACKAGING ................................ 5 7 WARNINGS AND PRECAUTIONS .................................................................................
5 General ............................................................................................................................... 5 Opthalmologic ....................................................................................................................
ACETAZOLAMIDE is contraindicated for: • depressed sodium and/or potassium blood levels • in renal failure. • adrenal gland failure. • metabolic acidosis • some cases of hepatic cirrhosis • severe glaucoma due to peripheral anterior synechias or in hemorrhagic glaucoma • long term use in chronic non-congestive angle closure glaucoma
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Acetazolamide in Canada.
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6 Respiratory ......................................................................................................................... 1 Special Populations ................................................................................................
2 Breast-feeding .................................................................................................... 3 Pediatrics............................................................................................................
6 8 ADVERSE REACTIONS................................................................................................. 1 Adverse Reaction Overview ................................................................................... 5 Post-Market Adverse Reactions.............................................................................
7 9 DRUG INTERACTIONS ................................................................................................ 2 Drug Interactions Overview ................................................................................... 4 Drug-Drug Interactions ..........................................................................................
5 Drug-Food Interactions .......................................................................................... 6 Drug-Herb Interactions .......................................................................................... 7 Drug-Laboratory Test Interactions.........................................................................
7 10 CLINICAL PHARMACOLOGY ........................................................................................ 7 11 STORAGE, STABILITY AND DISPOSAL .......................................................................... 7 12 SPECIAL HANDLING INSTRUCTIONS............................................................................
8 PART II: SCIENTIFIC INFORMATION ....................................................................................... 9 13 PHARMACEUTICAL INFORMATION ............................................................................ 9 14 CLINICAL TRIALS ........................................................................................................
9 15 MICROBIOLOGY ........................................................................................................ 9 16 NON-CLINICAL TOXICOLOGY ......................................................................................
9 PATIENT MEDICATION INFORMATION ................................................................................ 10 ACETAZOLAMIDE (Acetazolamide Tablets) Page 4 of 15 Unclassified / Non classifié PART I: HEALTH PROFESSIONAL INFORMATION 1 INDICATIONS ACETAZOLAMIDE (acetazolamide tablets) is indicated: • To decrease ocular aqueous humor secretion in glaucoma (chronic, simple and secondary types).
• For use as an adjunct in the treatment of selected cases of epilepsy. • To alkalinize the urine in selected cases of salicylate overdosage. 1 Pediatrics Pediatrics: No data are available to Health Canada; therefore, Health Canada has not authorized an indication for pediatric use.
2 Geriatrics Geriatrics: No data are available to Health Canada; therefore, Health Canada has not authorized an indication for geriatric use. 2 CONTRAINDICATIONS ACETAZOLAMIDE is contraindicated for: • depressed sodium and/or potassium blood levels • in renal failure.
• adrenal gland failure. • metabolic acidosis • some cases of hepatic cirrhosis • severe glaucoma due to peripheral anterior synechias or in hemorrhagic glaucoma • long term use in chronic non-congestive angle closure glaucoma 3 SERIOUS WARNINGS AND PRECAUTIONS BOX • The patient should be cautioned to report any unusual skin rash.
Severe Cutaneous Adverse Reactions such as Stevens Johnsons Syndrome, Erythema Multiforme, Toxic Epidermal Necrolysis and Acute Generalised Exanthematous Pustulosis may occur with acetazolamide. Hypersensitivity reactions may recur if a […]