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(40 MMOL/L) POTASSIUM CHLORIDE IN is a brand name for Potassium Chloride, supplied as a solution. The medicine, its uses, side effects and dosage are the same regardless of brand.
Verbatim from this product's HC label. Tap a section to expand.
Potassium Chloride in 5% Dextrose Injection, USP is contraindicated in the following conditions: Patients who are hypersensitive to this drug or to any ingredient in the formulation or component of the container. For a complete listing, see the SUMMARY PRODUCT INFORMATION section of the Prescribing Information.
Known allergy to corn or corn products since dextrose in the products is purified from corn. Clinically significant hyperglycemia Clinically significant hyperkalemia WARNINGS AND PRECAUTIONS WARNINGS Hypersensitivity Reactions Hypersensitivity/infusion reactions, including anaphylaxis, have been reported with other potassium chloride and dextrose products.
The infusion must be stopped immediately if signs or symptoms of suspected hypersensitivity/infusion reactions develop. Appropriate therapeutic countermeasures must be instituted as clinically indicated. Since dextrose in Potassium Chloride in 5% Dextrose Injection, USP is derived from corn, the product should not be used in patients with known allergy to corn or corn products (see CONTRAINDICATIONS section).
, hyperkalemic periodic paralysis, paramyotonia congenita, and potassium-aggravated myotonia/paramyotonia). Potassium Chloride in 5% Dextrose Injection, USP should be administered with caution to patients who are at risk of experiencing hyperosmolality, acidosis, or undergoing correction of alkalosis (conditions associated with a shift of potassium from intracellular to extracellular space) and patients treated concurrently or recently with agents or products that can cause hyperkalemia or increase the risk of hyperkalemia (see Drug Interactions).
Other groups of patients in whom Potassium Chloride in 5% Dextrose Injection, USP should be used with caution include patients with cardiac arrhythmia. Arrhythmias can develop at any time during hyperkalemia. Frequently, mild or moderate hyperkalemia is 4 of 14 asymptomatic and may be manifested only by increased serum potassium concentrations and, possibly, characteristic ECG changes.
Hyperkalemia may result even with low dosage. Please refer to OVERDOSAGE for Hyperkalemia symptoms and treatments. Use in Patients with or at risk of Severe Renal Impairment Potassium Chloride in 5% Dextrose Injection, USP should be administered with particular caution, to patients with or at risk of severe renal impairment.
In such patients, administration of Potassium Chloride in 5% Dextrose Injection, USP may result in or predispose to hyperkalemia and/or fluid overload. , pulmonary congestion) and peripheral edema. Particular caution should be taken in patients with conditions that may cause sodium retention, fluid overload, and edema (central and peripheral).
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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Hyponatremia and a decrease in extracellular sodium concentrations related to hyperglycemia causing a transcellular shift of water. Infusion of Potassium Chloride in 5% Dextrose Injection, USP corresponds to the increasing body’s load of free water, possibly leading to hypoosmotic hyponatremia.
The risk of dilutional states is inversely proportional to the electrolyte concentrations of the injection. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentrations of the injection.
Particular caution is advised in patients at increased risk of and from water and electrolyte disturbances that could be aggravated by increased free water load, hyperglycemia or possibly required insulin administration (See Hyperglycemia).
Hyponatremia Glucose 5% preparations are isotonic solutions. In the body, however, glucose containing fluids can become extremely physiologically hypotonic due to rapid glucose metabolization. 5 of 14 Monitoring of serum sodium is particularly important for hypotonic fluids.
Potassium Chloride in 5% Dextrose Injection, USP has an osmolarity of 292-332 mOsmol/L. Please refer to Table 1 of SUMMARY PRODUCT INFORMATION for exact osmolarity values. Depending on the tonicity of the solution, the volume and rate of infusion, and depending on a patient’s underlying clinical condition and capability to metabolize glucose, intravenous administration of glucose can cause electrolyte disturbances, most importantly hypo- or hyperosmotic hyponatremia.
High volume infusion must be used under specific monitoring in patients with cardiac or pulmonary failure, and in patients with non-osmotic vasopressin release (including SIADH), due to the risk of hospital-acquired hyponatremia. Acute hyponatremia can lead to acute hyponatremic encephalopathy (brain edema) characterized by headache, nausea, seizures, lethargy and vomiting.
Patients with brain edema are at particular risk of severe, irreversible and life-threatening brain injury. The risk for developing hyponatremia is […]